Evaluating Nuclei Concentration in Amyloid Fibrillation Reactions Using Back-Calculation Approach

Evaluating Nuclei Concentration in Amyloid Fibrillation Reactions Using Back-Calculation Approach

BACKGROUND In spite of our extensive knowledge of the more than 20 proteins associated with different amyloid diseases, we do not know how amyloid toxicity occurs or how to block its action. Recent contradictory reports suggest that the fibrils and/or the oligomer precursors cause toxicity. An estimate of their temporal concentration may broaden understanding of the amyloid aggregation process....

Back calculation of blood alcohol concentration.

′ π ) . . . reactions in nuclei

We study the inclusive (e, eN), (e, eNN), (e, eπ), (e, eπN) reactions in nuclei using a Monte Carlo simulation method to treat the multichannel problem of the final state. The input consists of reaction probabilities for the different steps evaluated using microscopical many body methods. We obtain a good agreement with experiment in some channels where there is data and make predictions for ot...

Spatially controlled amyloid reactions using organic electronics.

Abnormal protein aggregates, so called amyloid fibrils, are mainly known as pathological hallmarks of a wide range of diseases, but in addition these robust well-ordered self-assembled natural nanostructures can also be utilized for creating distinct nanomaterials for bioelectronic devices. However, current methods for producing amyloid fibrils in vitro offer no spatial control. Herein, we demo...

Neutron Transfer Reactions for Deformed Nuclei Using Sturmian Basis

We study the spin-parity distribution P(J,E) of Gd excited states above the neutron separation energy that are expected to be populated via the neutron pickup reaction Gd(He,He)Gd. In general, modeling of the spin-parity distribution is important for the applicability of the surrogate reaction technique as a method of deducing reaction cross sections. We model excited states in Gd as rotational...